Figure 3.

miR-23b knockdown inhibits nerve injury in MCAO mice. A, miR-23b expression in mouse brain tissues measured by RT-qPCR. B, Area of brain infarction in mice detected by TTC staining. C, Neurological scores of mice in each group. D, HE (400 ×) staining of brain tissues of mice. E, TUNEL (400 ×) staining of apoptosis in brain tissues of mice. F, Latency of mice examined by Morris water maze test. G, Time of mice spent in target quadrant examined by Morris water maze test. H, Times of mice crossing the platform examined by Morris water maze test. *p < 0.05 vs. the sham group; #p < 0.05 vs. MCAO + LV-Anti-NC group. Measurement data were expressed by mean ± standard deviation. One-way ANOVA was conducted for multi-group data comparison, followed by Tukey's post hoc test. Pairwise comparison of neurological scores in panel C was analyzed by non-parametric test Mann-Whitney test. n = 10.