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. 2021 Aug 26;17(13):3672–3688. doi: 10.7150/ijbs.60110

Figure 2.

Figure 2

EndoA2 protects the heart from MI. (A-E) The representative images and analysis results of echocardiographic assessment of mouse hearts subjected to MI. Intramyocardial injection of Ad-EndoA2 abrogated the ischemia-induced decreased cardiac function. (n=8 mice, ** p <0.01 vs. sham; ## p <0.01 vs. MI+Ad-lacZ). (F) Cardiomyopathy gene expression was determined by qRT-PCR. Intramyocardial injection of Ad-EndoA2 decreased the cardiomyopathy gene expression compared with MI+Ad-lacZ group (n=8 mice, ** p <0.01 vs. sham; ## p <0.01 vs. MI+Ad-lacZ). (G-H) The representative images and analyses of TTC staining assessment of the hearts subjected to MI. Injection of Ad-EndoA2 decreased MI-induced infarct size (n=5 mice, ## p <0.01 vs. MI+Ad-lacZ). (I) The representative images of H&E staining assessment of the arrangement of striated muscle after MI. Injection of Ad-EndoA2 improved arrangement of striated muscle compared with MI+Ad-lacZ group. Scale bars: 500 µm (n=5 mice). (J-K) The representative images and analyses of Masson's trichrome staining assessment of fibrosis after MI. Injection of Ad-EndoA2 diminished fibrosis compared with MI+Ad-lacZ group. Scale bars: 500 µm (n=5 mice, ## p <0.01 vs. MI+Ad-lacZ).