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. 2021 Aug 19;17(13):3595–3607. doi: 10.7150/ijbs.62471

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BANCR knockdown promotes the sensitivity of HepG2/SO and HCCLM3/SO cells to SO. (A) Under SO treatment, the IC50 value of the sh-BANCR group (HepG2/SO) was significantly down-regulated, compared to the control group and the sh-NC group (cell viability assay was used). One-way ANOVA was used. * Compared with the control group or sh-NC group, P<0.05; # Compared with the control group or sh-NC group, P<0.05. (B) Under SO treatment, the IC50 value of the sh-BANCR group (HCCLM3/SO) was significantly down-regulated, compared to the control group and the sh-NC group (cell viability assay was used). One-way ANOVA was used. * Compared with the control group or the sh-NC group, P<0.05; # Compared with the control group or sh-NC group, P<0.05. (C) BANCR knockdown enhanced cell apoptosis in HepG2/SO and HCCLM3/SO cells. (D) BANCR knockdown inhibited the number of EdU-positive cells in HepG2/SO and HCCLM3/SO cells. SO: Sorafenib; BANCR: BRAF-activated non-protein coding RNA. The scale bar is 50 um.