Table 1.
M5C RNA methylation induced cell migration and metastasis
| Cell type | M5C component | Role | Effects | Refs |
|---|---|---|---|---|
| Bladder urothelial carcinoma | NSUN2 & YBX1 | Writer & reader | NSUN2 stabilize the mRNA of HDGF, while YBX1 bind to m5C methylation with a partner protein ELAVL1 and promote cell growth, tumor progression and metastasis | 54 |
| Breast cancer | NSUN2 | Writer | NSUN2 overexpression promotes metastasis and invasion of breast cancer | 109 |
| Breast cancer | NSUN6 | Writer | The antagonizing lncRNA for YAP activation inhibits activity of the protein serine kinase MST1 in a NSUN6-dependent way, which facilitates bone metastasis in breast cancer | 125 |
| ESCC | NSUN2 | Writer | NSUN2 methylated lncRNA bind to chromatin regulator BPTF and promotes MMPs expression through ERK pathway | 111 |
| Glioma | NSUN2 | Writer | NSUN2 deficiency inhibits glioma cell migration by striking autotaxin and lysophosphatidic acid associated pathway | 100 |
| HCC | NSUN2 | Writer | NSUN2 methylated H19 bind to oncoprotein G3BP1, which may be associated with tumor genesis, migration and invasion | 113 |
| HEK 293 cell | NSUN2 | Writer | NSUN2 promote cell proliferation and migration by regulating oncogenes that are associated with cell cycle, focal adhesion, TGF-β signaling pathway and Notch signaling pathway | 52, 128 |
| HNSCC | NSUN5 & ALYREF | Writer & reader | ALYREF and NSUN5 are overexpressed in metastasis stage of head and neck squamous cell carcinoma | 119 |
| Neuroepithelial stem cells | NSUN2 | Writer | NSUN2 mediate FGF2 induced migration and differentiation of neuroepithelial stem cells | 106 |
| Prostate and breast cancer | NSUN2 | Writer | Expression level of NSUN2 and NSUN3 are regulated by proto-oncogenic isozymes (sphingosine kinases 1 and 2) in prostate metastasis cancer and breast cancer, by a possible mediation of epidermal growth factor associated cell migration | 126 |
| Prostate cancer | DNMTs | Writer | DNMT1, DNMT2, and DNMT3 are involeved in lymph node metastases of prostate cancer | 144 |
M5C writers and readers function as promoters of metastasis in pan-cancer. ESCC, esophageal squamous cell carcinoma. HCC, hepatocellular carcinoma. HNSCC, head and neck squamous cell carcinoma