Skip to main content
. 2021 Aug 13;17(13):3538–3553. doi: 10.7150/ijbs.63430

Figure 8.

Figure 8

CCNB2-mediated tumor cell metastasis could be abrogated by Cathepsin B inhibitor. (A) Cathepsin B mRNA expression in patients with primary (n=422) or recurrent glioma (n=271). (B) Cathepsin B mRNA expression in patients with LGG (n=188) or HGG (n=505). (C) Schematic model of senescent cells coculture and migration induction system. (D) Representative graphs of scratch-wound assay in Parental, Lenti-Vector, Lenti-CCNB2, Lenti-CCNB2+CA074 (Cathepsin B inhibitor) groups and (E) corresponding quantitative analysis; (b) are duplicates. Scale bar: 200 µm. (F) Quantification of vertically migrated cells. (G) Representative images of migrated cells in transwell assay of different groups. Scale bar: 100 µm. (H) Quantitative comparison and (I) pictures of invaded cells in different groups. Scale bar: 100 µm. *:P<0.05, **:P<0.01.