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. 2021 Aug 19;9:668377. doi: 10.3389/fcell.2021.668377

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Copyright © 2021 Wang, Wang, Zhang, Wu, Shi and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KIAA1429 is downregulated while ALKBH5 is upregulated in aorta samples from AD patients. (A) KIAA1429 was significantly downregulated while ALKBH5 was upregulated in the aorta specimens of AD patients compared to donors. (B,C) The low expression of KIAA1429 or high expression of ALKBH5 was confirmed in 25 pairs of aortic tissues from normal and AngII-induced AD mice. (D,E) The protein levels of KIAA1429 and ALKBH5 in aorta specimens from AD patients were significantly lower and higher than in aorta tissues from donors, respectively. Data are presented as the mean ± SEM (N ≥ 3 per group); *p < 0.05.