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. 2021 Aug 19;9:668377. doi: 10.3389/fcell.2021.668377

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Copyright © 2021 Wang, Wang, Zhang, Wu, Shi and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KIAA1429 enhances while ALKBH5 reduces m6A levels in HASMCs and HAECs. (A,B) The interference effects on KIAA1429 and ALKBH5 expression in HASMCs and HAECs were detected by qRT-PCR and Western blot. (C) Dot blot assays showed that overexpression or silencing of KIAA1429 significantly increased and decreased the level of m6A, respectively. (D) ALKBH5 could negatively regulate intracellular m6A levels. (E) The m6A level was lower in the aortic tissues from AD patients compared with donors. Data are presented as the mean ± SEM (N ≥ 3 per group); *p < 0.05.