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. 2021 Aug 19;9:668377. doi: 10.3389/fcell.2021.668377

FIGURE 6.

FIGURE 6

MiR-143-3p is a downstream target of KIAA1429 and ALKBH5. (A) MiR-143-3p is significantly downregulated in aortic tissues from AD patients. (B) A positive correlation between miR-143-3p and KIAA1429 (R = 0.4314, p = 0.0313) and a negative correlation between miR-143-3p and ALKBH5 (R = –0.4105, p = 0.0415) were identified by Pearson’s correlation coefficient analysis. (C) MiR-143-3p upregulation could partly restore the cell proliferation suppressed by KIAA1429 knockdown and downregulation of miR-143-3p could partly decrease cell multiplication promoted by KIAA1429 overexpression. (D) TUNEL apoptosis assay showed that enrichment of miR-143-3p could partly attenuate HAEC apoptosis induced by the silence of KIAA1429. (E,F) Upregulation of miR-143-3p could enhance the pro-proliferative effect of ALKBH5 knockdown on HASMCs and downregulation of miR-143-3p could weaken the anti-apoptotic effect of ALKBH5 knockdown on HAECs. Data are presented as the mean ± SEM (N ≥ 3 per group); *p < 0.05.