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. 2021 Aug 19;12:679407. doi: 10.3389/fphar.2021.679407

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Copyright © 2021 Yang, van der Stel, Lee, Bauch, Bevan, Walker, van de Water, Danen and Beltman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model fitting to classical mitochondrial inhibitors antimycin A and rotenone. (A) Flowchart illustrating the steps for single-cell analysis, normalization and model parameter estimation. (B, C) Quantified MMP dynamics and model fits upon exposure of HepG2 cells to antimycin A (B) and rotenone (C) at 10 concentrations. Gray lines and symbols represent individual experimental replicates, black dots and shading represent the mean and standard deviation of all replicates, and cyan lines represent best fits with the basic model. Note that all model parameters are kept free during parameter estimation.