FIGURE 6.

Model extension with ion leakage and/or compound decay improves the description of oligomycin data. MMP data in response to various concentrations of FCCP (gray line and dots indicate individual replicates; black dots and shading indicates the mean of replicates and 95% confidence intervals of means) are shown along with model simulations for best-fitting parameters of the basic model (cyan lines), of the model extended with concentration-independent compound decay (red lines), of the model with ion leakage and concentration-independent compound decay (black lines), and of the model with concentration-dependent compound decay (blue lines).