FIGURE 7.

The scheme of Deh mediated myocardial protective effects against sepsis. LPS was recognized by TLR4 and then activated TRAF6 mediated NF-κB phosphorylation. The phosphorylated NF-κB translocated from the cytoplasm into the nucleus and promoted the transcription of inflammatory factors. Once Deh was administered, TRAF6 was in inhibited and the NF-κB mediated inflammation was also attenuated. Moreover, Deh treatment promoted Nrf2 nucleus translocation. Nrf2 promoted HO-1 expression, which induced enhanced anti-oxidative meidators (including SOD, GSH-PX) and inhibited iNOS and ROS level.