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. 2021 Aug 19;12:730300. doi: 10.3389/fimmu.2021.730300

Figure 2.

Figure 2

Identification and functional enrichment analysis of differentially expressed Ex-mRNA. (A, D, G) The volcano plot and MA plot (A, D) and hierarchical clustering heatmap (G) of differentially expressed exosome mRNAs in Heroin AW versus HC (P < 0.05, fold change > 1.5). (B, E, H) The volcano plot and MA plot (B, E) and hierarchical clustering heatmap (H) of differentially expressed exosome mRNAs in Heroin PW versus HC (P < 0.05, fold change > 1.5). (C, F, I) The volcano plot and MA plot (C, F) and hierarchical clustering heatmap (I) of differentially expressed exosome mRNAs in Heroin AW versus Heroin PW (P < 0.05, fold change > 1.5). (J–M) Top enrichment of KEGG pathways related to differentially expressed exosome mRNAs in Heroin AW versus HC (J, K) and in Heroin PW versus HC (L, M).