Table 2.
Alterations of cytokine levels in heroin addicts (AW and PW) versus healthy controls (HC).
| mean | mean | mean | Healthy control vs Heroin AW | Healthy control vs Heroin PW | Heroin PW vs AW | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Healthy Control | Heroin AW | Heroin PW | Fold change | p.value | adj.p | Fold change | p.value | adj.p | Fold change | p.value | adj.p | |
| IL-2 | 7.02 ± 2.86 | 2.57 ± 4.93 | 14.17 ± 15.30 | 2.74 | 9.26E-04 | 2.78E-03 | 0.50 | 0.0467 | 0.0467 | 0.18 | 2.98E-03 | 4.48E-03 |
| IL-4 | 3.58 ± 1.43 | 15.56 ± 4.80 | 4.86 ± 2.82 | 0.23 | 4.58E-10 | 1.38E-09 | 0.74 | 0.06 | 0.06 | 3.20 | 1.05E-09 | 1.59E-09 |
| IL-5 | 13.85 ± 11.10 | 17.90 ± 28.34 | 21.71 ± 25.27 | 0.77 | 0.55 | 0.65 | 0.64 | 0.19 | 0.56 | 0.82 | 0.65 | 0.65 |
| IL-6 | 2.16 ± 1.66 | 6.71 ± 6.12 | 6.85 ± 16.04 | 0.32 | 3.77E-03 | 0.01 | 0.31 | 0.20 | 0.29 | 0.98 | 0.97 | 0.97 |
| IL-7 | 82.10 ± 27.61 | 236.96 ± 103.74 | 188.34 ± 100.88 | 0.35 | 1.96E-06 | 5.89E-06 | 0.44 | 1.05E-04 | 1.58E-04 | 1.26 | 0.14 | 0.14 |
| IL-8 | 21.67 ± 12.07 | 21.63 ± 11.37 | 29.89 ± 13.75 | 1.00 | 0.99 | 0.99 | 0.73 | 0.03 | 0.06 | 0.72 | 0.04 | 0.06 |
| IL-10 | 5.15 ± 4.11 | 39.11 ± 15.41 | 12.56 ± 15.31 | 0.13 | 2.97E-08 | 8.91E-08 | 0.41 | 0.0461 | 0.0461 | 3.12 | 5.83E-06 | 8.74E-06 |
| IL-13 | 7.26 ± 8.53 | 5.81 ± 5.41 | 6.83 ± 6.04 | 1.25 | 0.43 | 0.82 | 1.06 | 0.82 | 0.82 | 0.85 | 0.57 | 0.82 |
| IL-17A | 14.03 ± 6.97 | 37.17 ± 17.67 | 22.02 ± 111.03 | 0.38 | 1.12E-05 | 3.37E-05 | 0.64 | 5.41E-03 | 5.41E-03 | 1.69 | 2.56E-03 | 3.85E-03 |
| Basic FGF | 261.77 ± 140.75 | 257.16 ± 75.53 | 302.48 ± 144.97 | 1.02 | 0.87 | 0.87 | 0.87 | 0.30 | 0.45 | 0.85 | 0.22 | 0.45 |
| G-CSF | 254.41 ± 92.42 | 839.87 ± 264.43 | 290.23 ± 107.94 | 0.30 | 3.19E-09 | 8.75E-09 | 0.88 | 0.21 | 0.21 | 2.89 | 5.83E-09 | 8.75E-09 |
| Eotaxin | 169.89 ± 85.67 | 914.96 ± 329.08 | 149.04 ± 57.95 | 0.19 | 2.87E-09 | 4.31E-09 | 1.14 | 0.27 | 0.27 | 6.14 | 1.93E-09 | 4.31E-09 |
| MCP-1 | 63.13 ± 30.94 | 94.41 ± 30.14 | 49.02 ± 23.99 | 0.66 | 4.30E-04 | 6.45E-04 | 1.27 | 0.08 | 0.08 | 1.93 | 5.52E-06 | 1.66E-05 |
| MIP-1α | 4.02 ± 3.05 | 4.37 ± 1.21 | 6.39 ± 2.84 | 0.92 | 0.54 | 0.54 | 0.63 | 4.59E-03 | 8.93E-03 | 0.68 | 5.95E-03 | 8.93E-03 |
| PDGF-BB | 10095.47 ± 8850.47 | 2440.12 ± 1814.73 | 10243.75 ± 8533.97 | 4.14 | 6.71E-06 | 2.01E-05 | 0.99 | 0.95 | 0.95 | 0.24 | 4.83E-04 | 7.25E-04 |
| TNFα | 77.91 ± 18.43 | 69.50 ± 18.56 | 104.23 ± 33.11 | 1.12 | 0.11 | 0.11 | 0.75 | 2.30E-03 | 3.45E-03 | 0.67 | 2.21E-04 | 6.62E-04 |
| VEGF | 578.83 ± 547.43 | 1244.71 ± 498.93 | 405.09 ± 241.34 | 0.47 | 3.81E-05 | 5.71E-05 | 1.43 | 0.11 | 0.11 | 3.07 | 2.55E-07 | 7.64E-07 |
Values are showed as mean ± SD. P-values marked with bold indicate statistically significant differences between the groups.