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Protein arginine methyltransferases (PRMT) that methylate the nitrogen of specific arginine residues in proteins are classified into three types: (i) type I PRMTs (i.e., PRMT1, PRMT2, PRMT3, PRMT4, PRMT6, and PRMT8) catalyze the asymmetric NG, NG-dimethylarginine (ADMA); (ii) type II PRMTs (i.e., PRMT5 and PRMT9) catalyze the symmetric NG, NNG-dimethylarginine (ADMA); and (iii) type III PRMT (i.e., PRMT7) generates one methyl group to one side of nitrogen of arginine residue (MMA).
