Table 1.
Baseline characteristics for 46 women randomized to placebo or ω-3 fatty acid supplementation arms.
| Median (range) or N (%) | ||||
|---|---|---|---|---|
| Total | Placebo | ω-3 fatty acids | Comparison between arms | |
| Variable | N = 46 | N = 23 | N = 23 | P a |
| A) Demographic and risk variables | ||||
| Age, y | 53 (40–67) | 52 (40–63) | 53 (42–67) | 0.61 |
| Tyrer-Cuzick 10-yr risk, % | 8.4 (1.9–31.8) | 9.0 (3.0–12.7) | 7.6 (1.9–31.8) | 0.38 |
| Menopausal Peri | 11 (24%) | 6 (26%) | 5 (22%) | 1.00 |
| Post | 35 (76%) | 17 (74%) | 18 (78%) | |
| Genetic test Not tested | 36 (78%) | 19 (83%) | 17 (74%) | 0.15 |
| Wildtype | 6 (13%) | 1 (4%) | 5 (22%) | |
| Del mutation | 4 (9%) | 3 (13%) | 1 (4%) | |
| Prior precancerous No | 36 (78%) | 18 (78%) | 18 (78%) | 1.00 |
| Yes | 10 (22%) | 5 (22%) | 5 (22%) | |
| On OC/HRT? No | 29 (63%) | 16 (70%) | 13 (57%) | 0.54 |
| Yes | 17 (37%) | 7 (30%) | 10 (43%) | |
| B) Anthropomorphic and body composition variables | ||||
| Height, cm | 165 (155–175) | 163 (155–175) | 165 (155–175) | 0.15 |
| Weight, kg | 84.8 (69.2–115.6) | 81.3 (69.2–111.2) | 85.8 (75–115.6) | 0.081 |
| BMI, kg/m2 | 31.0 (27.9–42.4) | 30.7 (27.9–39.8) | 31.2 (27.9–42.4) | 0.28 |
| Waist circumference, cm | 100 (80–120) | 101 (80–115) | 100 (84–120) | 0.93 |
| Body fat, percent | 49 (37–55) | 46 (37–55) | 49 (42–53) | 0.028a |
| FMI, kg/m2 | 14.3 (10.1–21.2) | 13.5 (10.1–20.5) | 14.7 (11.7–21.2) | 0.11 |
aMann–Whitney nonparametric test, 2-sided. Similar lack of difference between randomized arms was observed if only the 42 women completing the 6-month intervention and evaluable for biomarkers were analyzed for baseline demographic and risk factors. Exceptions were the marginal statistical significance for body fat percent was lost (P = 0.078).