Table 3.
Median and range for baseline values and relative difference (percent) between baseline and 6 months for 16 serum biomarkers (of a total of 25 assessed), which exhibited a statistically significant change over timea either for the total cohort of 42 women completing the 6-month intervention or for groups defined by randomization or by dichotomization at 10% weight loss achieved at 6 months.
| Baseline values | Relative difference (%) | |||||
|---|---|---|---|---|---|---|
| Total cohort | Placebo | ω-3 FA | Wt loss <10% | Wt loss >10% | ||
| Analyte or ratio | N = 42 | N = 22 | N = 20 | N = 21 | N = 21 | |
| Adiponectin, μg/mL | 29 (10–90) | 15% b | 3% | 20% b | 3% | 30% b |
| Leptin, ng/mL | 30 (6–109) | −43%d | −42%d | −49%d | −25%c | −71%d |
| Adiponectin:Leptin Ratioe | 1.0 (0.2–16) | 115% d | 115% d | 133% d | 58% c | 274% d |
| Lipocalin-2, ng/mL | 255 (122–441) | −11% | 8% | −23%b | 10% | −23%b |
| Resistin, ng/mL | 38 (12–73) | −8%b | −6% | −11%b | −6% | −12%b |
| PAI-1, ng/mL | 83 (53–161) | −12%d | −12% | −11%c | −10% | −14%c |
| HGF, pg/mL | 304 (36–833) | −12%b | −10% | −13%b | 0% | −18%c |
| Omentin, ng/mL | 2.3 (1.4–48.3) | 5% | 0% | 9% b | 1% | 16% |
| Insulin, pg/mL | 259 (28–1805) | −23%c | −20% | −42%b | −16% | −54%c |
| CRP, μg/mL | 2.8 (0.2–20.3) | −18%b | −7% | −23%b | −13% | −44%b |
| IL6, pg/mL | 1.8 (0.4–296) | −10% | −5% | −17% | −19%b | 13% |
| SHBG, nmol/L | 61 (23–160) | 24% d | 17% c | 36% d | 13% c | 31% d |
| Free estradiol, pmol/L | 5.0 (0.9–52.8) | −13%b | −11% | −13% | −7% | −20%b |
| Free testosterone, pmol/L | 44 (1–2201) | −17%c | −15% | −24%b | −6% | −41%b |
| IGFBP2, nmol/L (n = 18) | 0.34 (0.06–0.67) | 86% c | 127% b | 41% | 32% | 140% b |
| IGF1:IGBP2 ratio (n = 18) | 19 (5–140) | −35% | −36% | −34% | −18% | −42%b |
Note: There is no adjustment for multiple comparisons so caution is advised in interpretation of the results.
Abbreviation: Wt, weight.
aWilcoxon nonparametric signed-rank test, 2-tailed, for within-group differences between baseline and 6 months.
bP < 0.05.
cP < 0.005.
dP < 0.0005.
eAdiponectin: leptin ratio is computed on the basis of adiponectin values in μg/mL and leptin values in ng/mL. Also assessed were TNFα, MCP-1, FGF-21, FABP4, estradiol, testosterone, IGF-1, IGFBP3, and ratio of IGF1: IGFBP3; no statistically significant changes detected.