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. 2021 Sep 3;17(9):80. doi: 10.1007/s11306-021-01831-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Changes in the levels of polyunsaturated fatty acids (PUFA) and oncometabolite 2-hydroxyglutarate (2-HG). a Methyl donor depletion causes a reduction in the levels of arachidonic acid (− 2.30, p < 0.04), a potential tumor-promoting metabolite. b Eicosapentaenoate (EPA) level was increased (1.33-fold) in MDD group and (2.0-fold, p < 0.013) in MDDR group indicating that the increased EPA level was sustained for at least seven weeks beyond dietary methyl donor repletion. c 2-hydroxyglutarate (2-HG), an oncometabolite was significantly reduced after methyl donor restriction (− 1.4-fold, p < 0.002. All groups marked with “a” have a statistically significant difference compared to groups marked with “b”