Table 3.
Hazard ratio (HR) and 95% confidence interval (CI) of the association of fish consumption, and risk of BC based on tertiles of intakes by gender and smoking status
| Tertile 1 | Tertile 2 | Tertile 3 | P-trend | Tertile 1 | Tertile 2 | Tertile 3 | P-trend | |
|---|---|---|---|---|---|---|---|---|
| HR (95%CI)* | HR (95%CI) | HR (95%CI) | HR (95%CI)* | HR (95%CI) | HR (95%CI) | |||
| Women | Men | |||||||
| Total fish and fish products | Total fish and fish products | |||||||
| Case/non-case | 80/44,180 | 94/37,374 | 161/34,470 | 172/17,309 | 379/23,895 | 651/26,459 | ||
| Person year | 479,226.23 | 377,769.02 | 281,772.08 | 186,702.27 | 225,122.36 | 215,306.94 | ||
| Crude | 1 (reference) | 0.80 (0.58, 1.10) | 0.60 (0.43, 0.83) | 0.001 | 1 (reference) | 0.75 (0.64, 0.90) | 0.68 (0.58, 0.81) | < 0.001 |
| Model 1a | 1 (reference) | 0.77 (0.55, 1.08) | 0.91 (0.61, 1.36) | 0.575 | 1 (reference) | 0.86 (0.72, 1.02) | 0.85 (0.71, 1.02) | 0.134 |
| Model 2b | 1 (reference) | 0.78 (0.55, 1.09) | 0.96 (0.63, 1.45) | 0.698 | 1 (reference) | 0.86 (0.72, 1.03) | 0.81 (0.67, 0.98) | 0.036 |
| Model 3c‡ | 1 (reference) | 1.07 (0.76, 1.51) | 0.77 (0.39, 1.50) | 0.658 | 1 (reference) | 0.85 (0.71, 1.02) | 0.79 (0.65, 0.97) | 0.047 |
| HR (95%CI)* | HR (95%CI) | HR (95%CI) | P-trend | HR (95%CI)* | HR (95%CI) | HR (95%CI) | P-trend | HR (95%CI)* | HR (95%CI) | HR (95%CI) | P-trend | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Never smoker | Former smoker | Current smoker | ||||||||||
| Total fish and fish products | Total fish and fish products | Total fish and fish products | ||||||||||
| Cases/non-cases | 52/29,617 | 65/23,628 | 141/27,235 | 100/19,101 | 211/21,765 | 384/24,616 | 100/12,771 | 197/15,876 | 287/9078 | |||
| Person year | 323,773.01 | 231,752.69 | 213,767.02 | 204,627.5 | 206,186.25 | 194,456.23 | 137,527.99 | 164,952.43 | 88,855.77 | |||
| Crude | 1 (reference) | 0.72 (0.49, 1.05) | 0.55 (0.38, 0.80) | 0.001 | 1 (reference) | 0.83 (0.66, 1.04) | 0.73 (0.58, 0.91) | 0.005 | 1 (reference) | 0.79 (0.63, 0.99) | 0.78 (0.62, 0.99) | 0.089 |
| Model 1a | 1 (reference) | 0.93 (0.60, 1.43) | 1.24 (0.74, 2.08) | 0.434 | 1 (reference) | 0.84 (0.66, 1.08) | 0.79 (0.62, 1.01) | 0.072 | 1 (reference) | 0.87 (0.69, 1.10) | 0.90 (0.71, 1.16) | 0.535 |
| Model 2b | 1 (reference) | 0.93 (0.60, 1.44) | 1.24 (0.74, 2.10) | 0.416 | 1 (reference) | 0.85 (0.67, 1.09) | 0.77 (0.60, 0.99) | 0.042 | 1 (reference) | 0.87 (0.69, 1.10) | 0.88 (0.68, 1.13) | 0.364 |
| Model 3c‡ | 1 (reference) | 0.93 (0.60, 1.43) | 1.24 (0.74, 2.08) | 0.592 | 1 (reference) | 0.84 (0.66, 1.08) | 1.17 (0.72, 1.95) | 0.823 | 1 (reference) | 0.87 (0.65, 1.15) | 0.75 (0.44, 1.28) | 0.210 |
*HR hazard ratio, CI confidence interval
aAdjusted for age, sex, and total energy intake
bAdjusted for model 1 + vegetables and fruits intakes
c‡Adjusted for model 2 + red meat intake