Table 3.
Effect of metal binding site mutations on in vitro Zn(II) binding.
| AdcAII variant | Dissociation Constant KD (nM) |
|---|---|
| WT AdcAII | 18.7 ± 2.1 |
| AdcAIIH65A | 174.4 ± 30.7 |
| AdcAIIH141A | 247.8 ± 63.8 |
| AdcAIIH205L | 44.7 ± 3.6 |
| AdcAIIE280Q | 159.3 ± 42.7 |
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