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. 2021 Aug 19;12:716654. doi: 10.3389/fphys.2021.716654

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Copyright © 2021 Chen, Wang, Gao, Ma, Xue and Hao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential correlations between the gut microbiota and liver metabolites. The red line represents a positive correlation, and the green line represents a negative correlation. The thickness of the line represents the correlation coefficient. (A) Correlation between 52 different intestinal bacterial genera and the top 100 metabolites. (B) Bacteria that are positively or negatively related to deoxycholic acid. (C) Bacteria that are positively or negatively related to glucosamine. (D) Bacteria that are positively or negatively related to tauroursodeoxycholic acid. (Student’s t-test, p < 0.05, Spearman correlation analysis, | correlation coefficient| ≥ 0.6).