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. 2021 Aug 19;12:720672. doi: 10.3389/fphys.2021.720672

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Copyright © 2021 Yu, Feng, Li, Liu, Liao, Luo, Wei, Huang, Zhang and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic pathway analysis based on differentially expressed metabolites identified in the plasma of patients with GCC and PCC. (A) Kyoto Encyclopedia of Genes and Genomes metabolic pathways database showed that the sphingolipid metabolism is the only statistically significant pathway. The X-axis represents the pathway impact, and the Y-axis represents –log10 (p). (B) Metabolite set enrichment analysis showed that the sphingolipid metabolism is the statistically significant pathway based on differentially expressed metabolites identified in the plasma of patients with GCC and PCC. GCC, good collateral circulation; PCC, poor collateral circulation.