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. 2021 Aug 19;8:713021. doi: 10.3389/fcvm.2021.713021

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Copyright © 2021 Han, Liu, Zhang, Chen, Luo, Ding, Lu, Wu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical Abstract — The composite hydrogel formed by SF and SS did not induces strong immune responses and improved the beneficial effect of the UMSC-Exo by promoting angiogenesis and the wound repair. The composite hydrogel can serve as an excellent media for exosomes delivery and tissue repair.