Table 2.

Subgroup efficacy by subgroups

Trial	Endpoint	No oxygen	Low-standard flow oxygen	High flow oxygen	NAME	Mechanical ventilation
Wang et al.[13]	Time to two-point improvement	NT	Not reported by subgroups
ACTT [14▪▪]	Time to recovery (higher HR is better)	H.R.: 1.29 (0.91–1.83)	H.R.: 1.45 (1.18–1.79)	HR: 1.09 (0.76–1.57)		HR: 0.98 (0.70–1.36)
SIMPLE-Moderate [15]	Clinical Status on day 11 (higher is better)	OR: 1.65 (1.09–2.48)	NT
Solidarity [16]	Mortality (lower H.R. is better)	HR: 0.90 (2.0% vs. 2.1%)	HR: 0.85 (12.2% vs. 13.8%)		HR: 1.2 (43.0% vs. 37.8%)

This population was not part of the trial population evaluated in the trial.

ACTT, Adaptive COVID-19 Treatment Trial; HR, hazard ratio; NT, not tested; OR, odds ratio.