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Administration of doxycycline in either control or supplemental linoleic acid diet resulted in a significant reduction in tafazzin (Taz; A) mRNA and (B) protein content in soleus of Taz knockdown (TazKD) male mice compared to their wild-type littermates. Values are means ± SEM, n=3 for Taz mRNA. WT, wild type; TazKD, Taz knockdown; Con, chow diet; and LA, linoleic acid-supplemented diet.
