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Subsarcolemmal mitochondria isolated from whole hindlimb of TazKD male mice demonstrated (A) lower supercomplex formation compared to wild-type littermates, which was not significantly increased (p=0.14) with 8weeks of supplemental linoleic acid diet. (B) Example membrane from blue-native polyacrylamide gel electrophoresis. Values are means ± SEM, n=3. WT, wild type; TazKD, tafazzin knockdown; Con, chow diet; LA, linoleic acid-supplemented diet; and SC, supercomplex.
