Table 2.
Isometric muscle function in response to 8 weeks of control or supplemental linoleic acid diet in soleus of doxycycline-induced tafazzin knockdown mice and their wild-type littermates.
| WT | TazKD | |||
|---|---|---|---|---|
| Con | LA | Con | LA | |
| Pt (mN) | 20±2 | 20±4 | 21±5 | 18±2 |
| Pt/CSA (mN/mm2) | 15±2 | 14±2 | 18±5 | 14±2 |
| Po (mN) | 168±26 | 154±14 | 132±16 | 138±14 |
| Po/CSA (mN/mm2) | 127±23 | 110±15 | 116±19 | 106±13 |
| +dP/dt (mN/msec) | 1.0±0.1 | 0.8±0.1 | 0.8±0.2 | 0.8±0.1 |
| −dP/dt (mN/msec)* | 0.17±0.02 | 0.15±0.03 | 0.10±0.04 | 0.13±0.03 |
| Pt:Po | 0.12±0.01 | 0.13±0.02 | 0.15±0.02 | 0.13±0.02 |
Values are means ± SEM, n=5; WT, wild-type; TazKD, tafazzin knockdown; Con, chow diet; LA, linoleic acid-supplemented diet; Pt, peak twitch force; CSA, cross-sectional area; Po, peak tetanic force; +dP/dt, rate of force development; and −dP/dt, rate of force relaxation.
*
Denotes main effect for genotype.