Fig. 2.

Risk estimates reported for the association between NSAID use and proximal colon cancer by medication type and study design. ^aEstimates were log-transformed prior to generation of the pooled estimate; ^bExcluding Cheung 2020 [67] due to different outcome measure, i.e., post-colonoscopy proximal colon cancer within 3 years; ^cExcluding Allison 2006 [59] for which no association was found but no risk estimate was reported; ^dCrude estimate reported as calculated from the number of events and the numbers of participants or person-time reported in article. CI Confidence interval, HR Hazard Ratio, I-squared test for heterogeneity, NA Not Applicable, NR Not reported, NSAID Non-steroidal anti-inflammatory drug, OR Odds Ratio, p p-value for heterogeneity, RCT Randomized controlled trial, RR Risk/Rate Ratio