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. 2021 Jul 5;32(10):1047–1061. doi: 10.1007/s10552-021-01472-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Risk estimates reported for the association between exogenous hormone use and proximal colon cancer by medication type. ^aEstimates were log-transformed prior to generation of the pooled estimate; ^bEstimate only age-adjusted; ^cExcluding Lin 2007 [54] for which no association was found but no risk estimate was reported; ^dSummary estimate obtained from stratified estimates using random effects meta-analysis methods. CI Confidence interval, HR Hazard Ratio, HRT Hormone Replacement Therapy, I-squared test for heterogeneity, OR Odds Ratio, NR Not reported, p p-value for heterogeneity, R Risk/Rate Ratio