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. 2021 Aug 19;13:707950. doi: 10.3389/fnagi.2021.707950

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Copyright © 2021 Alldred, Lee, Stutzmann and Ginsberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pronounced downregulation of members of the oxidative phosphorylation pathway in trisomic basal forebrain cholinergic neurons (BFCNs). The Kyoto Encyclopedia of Genes and Genomes (KEGG) derived oxidative phosphorylation pathway is rendered by Pathview, with significantly dysregulated genes highlighted for each complex from the medial septal nucleus (MSN) BFCNs as assayed by single population RNA-seq (Alldred et al., 2021). Downregulation is shown as color coded log fold change difference (LFC) with green depicting downregulation and red depicting upregulation. Note no genes within the oxidative phosphorylation pathway were upregulated.