Figure A5.

Low- vs. multi-fidelity arrhythmogenicity mismatch. Mismatch between the low-fidelity midwall cell proxy and the full high-fidelity multiscale simulations for arrhythmogenic risk classification. For the male arrhythmogenic risk classification (Left), this mismatch is limited. For the female arrhythmogenicity classification (Right), the multi-fidelity classifier predicts arrhythmogenesis at larger {I_Kr, I_CaL} channel blocking combinations than the low-fidelity risk classifier.