Table 1.
Sex-specific subcellular ion channel activity.
| Male | Female | |||||
|---|---|---|---|---|---|---|
| Epi | Mid | Endo | Epi | Mid | Endo | |
| I NaL | 0.77 | 1.06 | 1.06 | 0.65 | 0.93 | 0.93 |
| I to | 4.00 | 4.00 | 1.00 | 4.00 | 4.00 | 1.00 |
| I pCa | 0.70 | 1.97 | 0.79 | 1.26 | 3.17 | 1.27 |
| I Kr | 1.20 | 0.88 | 1.10 | 0.96 | 0.70 | 0.87 |
| I Ks | 1.16 | 1.10 | 1.10 | 0.93 | 0.88 | 0.88 |
| I K1 | 1.07 | 1.39 | 1.07 | 0.76 | 1.18 | 0.91 |
| INaCa,i / INaCa,ss | 1.10 | 1.41 | 1.01 | 1.07 | 1.38 | 0.99 |
| I NaK | 0.92 | 0.70 | 1.00 | 0.87 | 0.70 | 1.00 |
| I Kb | 0.82 | 1.25 | 1.25 | 0.42 | 0.68 | 0.68 |
| Ca2+ release | 1.13 | 1.68 | 0.99 | 0.89 | 1.72 | 1.01 |
| Ca2+ uptake | 1.33 | 0.94 | 0.94 | 1.85 | 1.08 | 1.08 |
| [CMDN] | 0.97 | 0.92 | 0.92 | 1.28 | 1.11 | 1.11 |
Sex-specific subcellular ion channel activity. Sex-specific and transmurally varying subcellular ion channel activity scaling used in computational models based on mRNA and protein ion channel subunit expression and functional data (Näbauer et al., 1996; Szabó et al., 2005; Soltysinska et al., 2009; Gaborit et al., 2010; O'Hara et al., 2011; Yang and Clancy, 2012).