Table 3.
Effects of reconsolidation therapies for PTSD treatment in adult participant RCTs.
| Reconsolidation procedure | Outcome | Comparisons | Participants (n) | RR/SMD (95% CI) | I2 | GRADE Judgement |
|---|---|---|---|---|---|---|
| All pharmacological/ECT/psychological reconsolidation interventions | PTSD severity 1–4 weeks | 11 | 372 | SMD: −1.42 (−2.25 to −0.58) | 91% | Very low |
| All pharmacological/ECT/psychological reconsolidation interventions | Re-experiencing severity 1–4 weeks | 7 | 235 | SMD: −2.29 (−3.55 to −1.04) | 92% | Very low |
| All pharmacological/ECT reconsolidation interventions | PTSD severity 1–4 weeks | 7 | 215 | SMD: −0.26 (−0.60, 0.08) | 30% | Very low |
| propranolol & MR | PTSD severity 1 week | 2 | 78 | SMD: 0.32 (−0.93 to 1.56) | 80% | Very low |
| RTM | PTSD severity 2 weeks | 4 | 157 | SMD: −3.64 (−5.07 to −2.20) | 83% | Very low |
| RTM | Re-experiencing severity 2 Weeks | 4 | 157 | SMD: −3.60 (−4.85 to −2.35) | 78% | Very low |
PTSD post-traumatic stress disorder, n number of participants included at the final assessment, RR relative risk,
SMD standard mean difference, CI confidence interval, ECT electroconvulsive therapy, MR memory reactivation, RTM reconsolidation of traumatic memories.