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. Author manuscript; available in PMC: 2021 Sep 6.
Published in final edited form as: Cancer Gene Ther. 2021 Mar 4;28(9):924–934. doi: 10.1038/s41417-021-00310-y

Figure 1. GC tumor microenvironment.

Figure 1.

EBV and H. pylori perturb gastric mucosal immune equilibrium, favoring an innate immune phenotype characterized by macrophages exhibiting decreased CD204 expression and increased expression of CD206 and CXCL8, while eliciting tumor infiltrating lymphocytes associated with an IFN-γ response, Th17 cells, and activated T-cells that secrete IL-2, IL-12, IL-23, and IL-27. GC tumor cells escape immune surveillance through mechanisms such as increased expression of PD-L1 and CD47, decreased MHC class II antigen presentation, and inhibition of effector cell lysis.