Table 1.

Principal characteristics of studies included in this network meta-analysis

RCTs	Patient’s age (years)	Fresh/frozen cycles	Biopsy day/embryo stage	ET day/embryo stage	Ploidy analysis technique	PGT-A group (no of patients)	Control group (no of patients)	Outcome measures
Fiorentino et al., 2013 [4]	36–43	Fresh	D3/Cleavage	D5/Blastocyst	aCGH	34	31	OPR, CLB
Munné et al., 2019 [19]	25–40	Frozen	D5,6/Blastocyst	D5,6/Blastocyst	NGS	330	331	CPR, OPR, MR
Ozgur et al., 2019 [20]	≤35	Frozen	D5/Blastocyst	D5/Blastocyst	NGS	109	111	CPR, OPR, MR
Rubio et al., 2017 [5]	38–41	Fresh	D3/Cleavage	D5/Blastocyst	aCGH	100	105	CPR, OPR, MR, CLB
Scott et al., 2010 [22]	<43	Fresh	D5/Blastocyst	NP/Blastocyst	qPCR	13	15	CPR
Scott et al., 2013a [23]	21–42	Fresh	D5/Blastocyst	D6/Blastocyst	qPCR	72	83	CPR, OPR, MR
Scott et al., 2013b [11]	<35	Fresh	D3/Cleavage and D5/Blastocyst	D3/Cleavage and D5/Blastocyst	Microarray analysis and SNP	113	113	OPR
Sui et al., 2020 [27]	NP	Frozen	D5/Blastocyst	D5/Blastocyst	SNP	103	104	CPR1, OPR1, MR1, CLB
Treff et al., 2011 [24]	<43	Fresh	D5/Blastocyst	NP/Blastocyst	qPCR	37	39	CPR
Yang et al., 2013 [26]	<35	Frozen	D5/Blastocyst	D5/Blastocyst	aCGH	55	48	CPR, OPR, MR, CLB
Yang et al., 2017 [25]	<39	Frozen	D5/Blastocyst	D5/Blastocyst	NGS	85	84	CPR, OPR, MR

*RCTs, randomized controlled trials; D3, day 3; D5, day 5; ET, embryo transfer; PGT-A, preimplantation genetic testing for aneuploidy; NP, not provided; no, number; aCGH, array comparative genomic hybridization; NGS, next-generation sequencing; qPCR, quantitative polymerase chain reaction; SNP, single-nucleotide polymorphism; CPR, clinical pregnancy rates; OPR, ongoing pregnancy rates; MR, miscarriage rates; CLB, cumulative live-birth rates.¹Data obtained following personal communication