TABLE 4.
Resolved sensitivity of the COBAS AMPLICOR test and culture calculated on the basis of patient infection statusa
| Sex | Site | No. of patientsa | No. infectedb | Sensitivity (% [no. positive])c
|
||
|---|---|---|---|---|---|---|
| Culture | PCR of swabs | PCR of urine | ||||
| Female | Meaux | 160 | 1 | 100.0 (1) | 100.0 (1) | 100.0 (1) |
| Montreal | 794 | 26 | 61.5 (16) | 84.6 (22) | 80.0 (20)d | |
| Groningen | 299 | 19 | 47.4 (9) | 78.9 (15) | 89.5 (17) | |
| All | 1,253 | 46 | 56.5 (26) | 82.6 (38) | 84.4 (38)d | |
| Male | Meaux | 30 | 3 | 100.0 (3) | 100.0 (3) | 100.0 (3) |
| Montreal | 115 | 5 | 80.0 (4) | 80.0 (4) | 100.0 (5) | |
| Groningen | 106 | 11 | 45.5 (5) | 81.8 (9) | 81.8 (9) | |
| All | 251 | 19 | 63.2 (12) | 84.2 (16) | 89.5 (17) | |
The total number of patients with matched urine and swab specimens.
Patients were considered infected if culture was positive or if either the swab or the urine specimen was positive by the COBAS AMPLICOR test and was confirmed to be positive by the MOMP PCR.
Sensitivity was calculated by interpreting the results for all specimens initially COBAS AMPLICOR negative and IC negative for C. trachomatis as positive, negative, or inhibitory on the basis of the result of the repeat COBAS AMPLICOR test.
The urine from one infected patient was repeatedly inhibitory to the PCR. Data for this patient were excluded when calculating the sensitivity of the PCR with urine but were included when calculating the sensitivity of culture and PCR with swabs.