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. 2021 Sep 3;11:17642. doi: 10.1038/s41598-021-95045-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RBD-specific IgG antibody levels in symptomatic patients with SARS-CoV-2. (a). Levels of antibodies against SARS-CoV-2 RBD in patients at different times after symptom onset in 176 samples from 47 patients. Negative samples to COVID-19 (118 samples) were used as a negative control of ELISA. The ELISA data were expressed as ELISA Index (EI). Aligned dot plots and boxplots show EI values (dots), medians (middle line), third and first quartiles (boxes), while the whiskers display the minimum and maximum values. The dashed line indicates the cut-off value. Different letters (a, b) indicate statistical differences between each time in comparison with negative control determined by Kruskal–Wallis and Dunn’s multiple comparisons test (P < 0.05). The positivity in each time was expressed as a percentage (%). (b–i) Receiver operating characteristic (ROC) curves show the RBD IgG-ELISA's diagnostic performance in each time analyzed.