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. 2021 Sep 3;11:17642. doi: 10.1038/s41598-021-95045-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IgG antibody levels to SARS-CoV-2 RBD in patients who recovered (mild or severe) or who died with COVID-19. (a) Percentage of patients who recovered or died of COVID-19 and main comorbidities disease-associated. A detailed description of other comorbidities was shown in Table 1. (b) Levels of antibodies to SARS-CoV-2 RBD in patients who recovered (blue) or died (red) of COVID-19 or negative controls (black) were expressed as EI. (c) Paired analysis of RBD-specific IgG levels in survived patients displayed mild and severe clinical presentation of COVD-19. Aligned dot plots and boxplots show EI values (dots), medians (middle line), third and first quartiles (boxes), while the whiskers display the minimum and maximum values. The dashed lines indicate the cut-off values. Statistically significant differences were determined by Kruskal–Wallis and Dunn’s multiple comparisons test or Mann–Whitney test when appropriate (*P < 0.05). Not significant (ns).