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. 2021 Sep 3;11:17642. doi: 10.1038/s41598-021-95045-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Binding strength of IgG antibody to SARS-CoV-2 RBD (avidity) in COVID-19 patients. (a) IgG antibody avidity in patients who recovered (blue) or who died (red) with COVID-19. The IgG antibody avidity was expressed as the Avidity Index (AI %). The dash lines indicate the avidity range (low, intermediate, and high). (b) IgG antibody avidity to RBD concerning the time after symptom onset in recovered or dead groups. Aligned dot plots and boxplots show AI values (dots), medians (middle line), third and first quartiles (boxes), while the whiskers display the minimum and maximum values. Statistically significant differences were analyzed by Kruskal–Wallis and Dunn’s multiple comparisons test or Mann–Whitney test when appropriate (P < 0.05).