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. 2021 Sep 3;11:17642. doi: 10.1038/s41598-021-95045-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analyses of IgG subclasses to SARS-CoV-2 RBD in patients with COVID-19. (a) Kinetics of IgG1, IgG3, and IgG4 in COVID-19 patients in different time-points post the onset of the symptoms. The data were expressed as EI (dots), medians (middle line), third and first quartiles (boxes), while the whiskers display the minimum and maximum values. Numbers of patients (N) are indicated underneath. The positivity, in each time and respective IgG subclasses, was indicated as a percentage (%). Comparison of IgG1 (b), IgG3 (c), and IgG4 (d) in patients who recovered (blue) and who died (red) with COVID-19. Boxplots show the median of EI values and interquartile ranges. The dashed lines indicate the cut-off values. Statistically significant differences between groups were determined by the Mann–Whitney test each time (*P < 0.05).