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. 2021 Aug 27;53(8):1238–1249. doi: 10.1038/s12276-021-00661-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Serum LH and FSH levels of young (8 week old) p62^−/− and p62^+/+ female mice, n = 6–9. c, d RNA sequencing and RT-PCR detection of the relative expression of gonadotropin markers (Lhb, Fshb, and Gnrhr) in the pituitary. e Representative immunohistological images of pituitary sections stained for LH (green) and FSH (red) of young p62^+/+ or p62^−/− female mice. DAPI (blue), scale bars: 40 μm (left); 20 μm (right). f, g Relative mRNA expression of p62 and Lhb in the pituitary of PCOS model mice (WT + DHEA) and controls (WT + placebo), n = 3–4. h The correlation between pituitary p62 and relative Lhb mRNA expression in PCOS mice and control mice, n = 7. Statistical analyses were performed using Student’s t-test (a, b, d, f, j) and Pearson analysis (h). Data are presented as the mean ± SD. *P < 0.05; ***P < 0.001.