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. 2021 Aug 19;9:711531. doi: 10.3389/fcell.2021.711531

FIGURE 1.

FIGURE 1

Mechanosensing in the control of cell fate decisions: the cooperation between the Notch and YAP/TAZ pathways. (A,A’) Schematic representation of a mouse blastocyst. Trophectoderm (TE) cells are depicted in orange and Inner Cell Mass (ICM) cells in blue. (A’) Magnification of the framed region in (A). RBPJ and YAP–TEAD bind to the Cdx2 TE-enhancer and drive the TE fate (Rayon et al., 2014; Watanabe et al., 2017; Menchero et al., 2019). (B,B’) Schematic representation of a mouse embryonic pancreas. Cells fated to the ductal linage are colored in orange and cells fated to the endocrine lineage in blue. Multipotent pancreatic progenitors are depicted in gray. (B’) Magnification of the framed region in (B). The pancreatic progenitor cells sensing fibronectin activate the α5-integrin–F-actin-YAP axis. YAP–TEAD complex activates Hes1 expression. Further, Hes1 binds to the YAP–TEAD complex repressing Neurog3 expression and committing the progenitor cell to the ductal lineage (Mamidi et al., 2018).