FIGURE 3.

Mechanosensing in the control of cell fate decisions: Notch pathway being upstream of YAP/TAZ. (A) Schematic representation of a mouse embryonic cortex. Progenitor cells from a symmetric proliferative division are depicted in orange and two neurons deriving from a symmetric neurogenic division are depicted in blue. (A’) Scheme of cell division modes in the Pard3 genetic deletion context. At the early neurogenic phase, Notch activity increases YAP expression and promotes symmetric proliferative divisions (orange). At late neurogenic phase, the decrease of Notch activity results in lower YAP expression and the promotion of symmetric neurogenic divisions (blue) (Liu et al., 2018).