TABLE 4.

Epigenetic regulation of SIX transcription factor genes.

Gene	Epigenetic mechanism	Identified system	References
Six1	miR-448-5p	TGF-β induced lung fibrosis in asthma	Yang et al., 2019
	mirR-23a	Endometrial cancer	Li et al., 2019
	miR-30a	Prostate cancer	Zhu et al., 2016
	miR-488	Ovarian cancer	Yang et al., 2017
	miR-548a-3p	Warburg effect; breast cancer	Li L. et al., 2018
	miR-362	Cervical cancer	Shi and Zhang, 2017
	miR-185	Ovarian cancer, pediatric renal tumors, breast cancer	Imam et al., 2010
	miR-30a	Zebrafish skeletal muscle development	O’Brien et al., 2014
Six2	miR-335-5p	Breast cancer	Jia et al., 2020
	miR-181b	Kidney progenitors	Lyu et al., 2013
	Hypomethylation	Wilms tumor	Song et al., 2015
	Hypomethylation	Hepatic cell carcinoma	Sun et al., 2018
	Hypomethylation	Oral squamous cell carcinoma	Marcinkiewicz and Gudas, 2014
	Histone methylation associated with gene activation	Adult kidney epithelial cells	Omer et al., 2013
Six3	miR-196a	Xenopus eye development	Qiu et al., 2009
	Hypermethylation	Glioblastoma, astrocytoma	Yu et al., 2017, 2020
	Hypermethylation	Lung cancer	Mo et al., 2013
Six4	miR-384	Gastric cancer	Liu et al., 2020
	miR-203a	Bladder cancer	Na et al., 2019
	miR-621	Non-small cell lung carcinoma	Zhang et al., 2019
Six5	Increased repressive histone methylation and DNA hypermethylation	DM1	Filippova et al., 2001; Yanovsky-Dagan et al., 2015
Six6	Hypermethylation	Non-small cell lung carcinoma	Zhao et al., 2013
	Hypermethylation	Breast cancer	Lindqvist et al., 2014
	Hypomethylation	Retinal progenitor cells	Berdasco et al., 2017