Figure 4.

Postexposure prophylaxis for rabies with AAV-expressing RVNA in a mouse model. Groups of 6-week-old female BALB/c mice (n=10) were i.m. injected with 50×mouse LD₅₀ DRV. At 4 dpi, the mice was inoculated with 10¹² vector genomes of different AAVs via i.c. (A), i.v. (B) or i.n. route (C). (D) Groups of 6-week-old female BALB/c mice (n=10) were i.m. injected with 50×mouse LD₅₀ DRV and then i.c. inoculated with 10¹² vector genomes AAV-CR57 at 4, 5, and 6days post-inoculation. The mock group was inoculated with the same volume of DMEM. Mice were monitored once daily for 3weeks. The number of survivors in each group was recorded. Kaplan-Meier survival curves were used to determine the statistical significance of the survivor ratio. ^**p < 0.01.