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. 2021 Aug 19;11:680643. doi: 10.3389/fcimb.2021.680643

Figure 4.

Figure 4

The effect of different medications on vaginal microbiota. The diversity of the vaginal microbiota in each group is shown by the Chao index (A), Shannon–Wiener index (B), and principal coordinate analysis (PCoA) plot created based on the unweighted (C) and weighted (D) UniFrac distances. (E) Differentially abundant vaginal taxa detected using LDA in samples taken from the metformin and control groups. (F) Differentially abundant taxa detected in patients who received metformin combined with aspirin and controls. (A, B) P values were calculated using the one-sided Wilcoxon rank-sum tests. *p < 0.05 and **p < 0.01.