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. 2021 Aug 19;9:625877. doi: 10.3389/fbioe.2021.625877

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Copyright © 2021 Wang, Mei, Jiang, Jin, Xu, Li, Li, Meng, Zhu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Osteogenesis of in vivo implants. (A) The micro-architectural parameters displayed by the three-dimensional reconstructed μCT image, including bone mineral density, bone volume fraction, and trabecular thickness, and trabecular separation. (B) Images of toluidine blue staining. *P < 0.05 compared with Ti–M. ^#P < 0.05 compared with Ti–M–H1. ^&P < 0.05 compared with Ti–M–H4. **P < 0.01 compared with Ti–M. ^##P < 0.01 compared with Ti–M–H1. ^&&P < 0.01 compared with Ti–M–H4. The experiments were repeated three times.