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. 2021 Aug 19;12:673969. doi: 10.3389/fmicb.2021.673969

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Copyright © 2021 Qin, Shi, Xu, Yuan, Zheng, Zhang, Huang, Li, Jiang, Gao, Tian, Guo, Fu, Huang, Yang, Zhang, Li and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A landscape view of abundance changes in the six most predominant genera with age for both genders. The facets described the MRA of (A) Prevotella, (B) Streptococcus, (C) Lactobacillus, (D) Gardnerella, (E) Escherichia-Shigella, and (F) Veillonella, respectively, along with age for each sample. The smooth curves are formed using the geom_smooth function in R. Relative abundance of each genus was compared between genders at four age stages, and the asterisks indicate the significant level: **p < 0.05 (Wilcoxon test); ***p < 0.01.