Fig. 3.

Effect of Angptl3 ASO on reverse cholesterol transport in WD-fed CETP tg, LDLr−/− mice. A: Clearance of ³H-cholesterol from plasma over a 72-h period in mice treated with either control or Angptl3 ASO for 6 weeks and intraperitoneally injected with radiolabeled macrophages. The amount of ³H-cholesterol in (B) the liver, (C) feces, and (D) fecal bile acids (n = 9 for control ASO and n = 11 Angptl3 ASO groups). The asterisk denotes a significant difference (P < 0.05) between control ASO and Angptl3 ASO treatment groups. ANGPTL3, angiopoietin-like protein 3; ASO, antisense oligonucleotide; CETP, cholesteryl ester transfer protein; WD, Western diet.