Figure 1.

PPARα activation increases Sox9 expression and ATP abundance, and FXR suppresses Sox9 expression and ATP abundance in vitro

(A) QRT-PCR analysis of Acox1, Cpt1a, and Sox9 expression in HepG2 cells.

(B) ATP concentration measurements on HepG2 cells.

(C) QRT-PCR analysis of SHP, PDK4, and Sox9 expression in HepG2.

(D) ATP concentration measurements on HepG2.

(E) QRT-PCR analysis of Acox1, Cpt1a, and Sox9 expression in primary mouse hepatocytes.

(F) ATP concentration measurements on primary mouse hepatocytes.

(G) QRT-PCR analysis of SHP, PDK4, and Sox9 expression in primary mouse hepatocytes.

(H) ATP concentration measurements on primary mouse hepatocytes. Data are expressed as means ± SD. Comparisons between two groups were performed using the two-tailed Student's t-test. Significant difference is presented at the levels of ∗p < 0.05 and ∗∗p < 0.01.