TABLE 2.
Summary of significant statistical results on the physiological and subjective effects observed after administration of JWH-122 (n = 8) and JWH-210 (n = 8).
| Parameter | Mean ± SD | Student’s t-test comparison effects of JWH-122 vs. JWH-210 | ANOVA comparison time course effects of JWH-122 vs. JWH-210 | Dunnett’s test comparison to baseline | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| JWH-122 | JWH-210 | T (df = 14) | p- Value | F (df = 7,98) | p- Value | TC points | JWH-122 | JWH-210 | ||
| Physiological effects | ||||||||||
| SBP (mmHg) | Emax | 23.68 ± 14.50 | 4.87 ± 23.91 | 1.902 | 0.078 | |||||
| AUC0-4h | 24.66 ± 30.63 | 7.90 ± 53.90 | 0.764 | 0.457 | ||||||
| TC | 1.094 | 0.373 | NS | b | NS | |||||
| DBP (mmHg) | Emax | 8.81 ± 15.62 | 11.43 ± 12.85 | -0.367 | 0.719 | |||||
| AUC0-4h | 22.16 ± 23.52 | 18.10 ± 35.66 | 0.269 | 0.792 | ||||||
| TC | 1.951 | 0.070 | NS | a, c | NS | |||||
| HR (bpm) | Emax | 16.37 ± 21.69 | -0.37 ± 28.60 | 1.320 | 0.208 | |||||
| AUC0-4h | −0.34 ± 24.34 | −20.85 ± 390.6 | 1.261 | 0.228 | ||||||
| TC | 0.713 | 0.661 | NS | a, b | a | |||||
| T (ºC) | Emax | 0.15 ± 0.12 | 0.05 ± 0.33 | 0.807 | 0.433 | |||||
| AUC0-4h | 0.23 ± 0.33 | −0.06 ± 0.39 | 1.649 | 0.121 | ||||||
| TC | 3.054 | 0.006 | 1, 4 | NS | NS | |||||
| Subjective effects | ||||||||||
| Intensity (mm) | Emax | 2.75 ± 2.66 | 16.5 ± 27.02) | −1.432 | 0.174 | |||||
| AUC0-4h | 1.67 ± 1.98 | 10.34 ± 18.65 | −1.308 | 0.212 | ||||||
| TC | 1.801 | 0.095 | NS | NS | b | |||||
| High (mm) | Emax | 5.87 ± 5.98 | 19.00 ± 27.79 | −1.306 | 0.213 | |||||
| AUC0-4h | 3.68 ± 4.70 | 15.44 ± 26.77 | −1.224 | 0.241 | ||||||
| TC | 2.283 | 0.034 | NS | NS | b | |||||
| Hunger (mm) | Emax | 6.50 ± 11.13 | 29.70 ± 26.91 | −2.258 | 0.040 | |||||
| AUC0-4h | 10.41 ± 22.42 | 35.10 ± 30.35 | −1.850 | 0.085 | ||||||
| TC | 4.189 | <0.001 | 4 | NS | g | |||||
| Addiction Research Center Inventory (ARCI) form | ||||||||||
| MBG (euphoria) (score) |
Emax | 1 ± 1.41 | 1.37 ± 2.38 | −0.382 | 0.708 | |||||
| AUC0-4h | 1.25 ± 1.83 | 2.37 ± 3.74 | −7.64 | 0.457 | ||||||
| TC | 0.237 | 0.916 | NS | NS | d | |||||
| BG (intellectual efficiency and energy) (score) | Emax | 0.5 ± 0.53 | −0.25 ± 1.58 | 1.271 | 0.224 | |||||
| AUC0-4h | 0.37 ± 0.51 | −0.31 ± 1.79 | 1.043 | 0.315 | ||||||
| TC | 2.986 | 0.026 | NS | NS | NS | |||||
| A (amphetamine-like effects) (score) | Emax | 1.25 ± 1.38 | 0.75 ± 0.88 | 0.858 | 0.405 | |||||
| AUC0-4h | 1.25 ± 1.38 | 1.68 ± 2.10 | −0.491 | 0.693 | ||||||
| TC | 2.350 | 0.065 | NS | NS | d | |||||
| Evaluation of subjective effects of substances with abuse potential questionnaire (VESSPA-SP) | ||||||||||
| ANX (psychosomatic anxiety) (score) | Emax | 0.12 ± 0.17 | 0.43 ± 0.28 | −2.669 | 0.018 | |||||
| AUC0-4h | 0.19 ± 0.36 | 0.78 ± 0.68 | −2.116 | 0.053 | ||||||
| TC | 4.463 | 0.003 | 1 | NS | NS | |||||
Emax = peak effects 0–4 h (differences from baseline); AUC0−4 h = area under the curve from 0 to 4 h; TC = temporal course from 0 to 4 h. Emax measured by mmHg [SBP and DBP (systolic blood pressure and diastolic blood pressure)], bpm [HR (heart rate)], °C [T (cutaneous temperature)], mm [visual analog scale (VAS)], and score Addiction Research Center Inventory (ARCI) and expressed as mean and standard deviation. For Emax and AUC0−4, a Student’s t-test for independent sample was used (see statistical analysis). A p-value < 0.05 was considered statistically significant. For TC, a ANOVA was used to measured differences between JWH-120 and JWH-210 and statistical differences are presented as “time point” (p < 0.05) and “time point” (p < 0.01). For Dunnett’s test, statistical differences are presented as “a” p < 0.05, “a” p < 0.01 (times 0–10 m), “b” p < 0.05, “b” p < 0.01 (times 0–20 min), “c” p < 0.05, “c” p < 0.01 (times 0–40 min), “d” p < 0.05, “d” p < 0.01 (times 0–1 h), “e” p < 0.05, “e” p < 0.01 (times 0–2 h), “f” p < 0.05, “f” p < 0.01 (times 0–3 h), and “g” p < 0.05, “g” p < 0.01 (times 0–4 h) (see statistical analysis). df = degrees of freedom.